Boston Children's Hospital

The Simoes-Costa lab focuses on decoding the molecular programs that orchestrate cell differentiation in the vertebrate embryo.

We employ functional genomics to characterize the gene regulatory circuits that control cell state transitions during...

We are interested in unlocking new paradigms of normal blood development with the long-term aim of building better models of childhood blood diseases.  The process of blood formation changes over a lifetime: the blood stem cells formed in the embryo...

The Flynn lab  is focused on the exploration and discovery of how biopolymers like RNA and glycans work together to control cellular processes in the context of human disease.

Glycans regulate a myriad of essential cellular functions, especially in the...

José Ordovas-Montañes seeks to understand the principles of how inflammation drives memory formation in human barrier tissues, in order to program and re-program them in disease.

We are developing a training environment where we apply emerging techniques...

Scott Armstrong studies the mechanisms of cancer development, focusing on leukemia. One major interest of this lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia.

The...

Alessandra Biffi is actively involved in gene therapy trials for genetic diseases of childhood. Her research focuses on enhancing the efficacy of HSC-based therapeutic approaches for LSDs with severe nervous system involvement.

Hematopoietic stem cell...

April Craft’s lab studies the development of cartilage and other synovial joint tissues, with hopes of applying this knowledge toward the development of therapeutics for disease attenuation and tissue regeneration and repair.

To achieve this goal, they...

The Melero-Martin laboratory aims to develop cell-based technologies that will allow engineering vascularized tissues in vivo using postnatal progenitor cells obtained from patients by non-invasive means

Stem cells and tissue engineering hold great promise...

Dr. Vijay Sankaran’s laboratory studies how human genetic variation impacts human blood cell production or hematopoiesis in health and disease.

The Sankaran Laboratory utilizes human genetics to refine our understanding of hematopoiesis and how this...

Markus Frank's laboratory defined a novel function for ABCB5 in cancer stem cell maintenance and tumor growth, and investigates the therapeutic efficacy of ABCB5 targeting in melanoma and additional ABCB5-expressing human malignancies.

Research in the...