Blood Diseases

Jose Cancelas is a MD, PhD, hematologist with a broad background in transfusion medicine, cell therapies, hematology, and stem cell biology. He is the executive director of the Connell and O’Reilly Cell Manipulations Core Facility at Dana Farber Cancer...

We are interested in unlocking new paradigms of normal blood development with the long-term aim of building better models of childhood blood diseases.  The process of blood formation changes over a lifetime: the blood stem cells formed in the embryo...

The Van Galen Laboratory studies normal and malignant hematopoiesis, with a focus on hematopoietic stem cell aging and the development of acute myeloid leukemia. Our projects span age-associated inflammatory pathways, targeted therapies for leukemia, and...

Zuzana Totova's laboratory is group of physicians and scientists who are passionate about tackling important questions in cancer biology, and aim to improve outcomes for cancer patients. Their research focuses on genetics and epigenetics of blood cancers

The Ebert lab focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS).

In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that predict...

Alessandra Biffi is actively involved in gene therapy trials for genetic diseases of childhood. Her research focuses on enhancing the efficacy of HSC-based therapeutic approaches for LSDs with severe nervous system involvement.

Hematopoietic stem cell...

The Melero-Martin laboratory aims to develop cell-based technologies that will allow engineering vascularized tissues in vivo using postnatal progenitor cells obtained from patients by non-invasive means

Stem cells and tissue engineering hold great promise...

Dr. Vijay Sankaran’s laboratory studies how human genetic variation impacts human blood cell production or hematopoiesis in health and disease.

The Sankaran Laboratory utilizes human genetics to refine our understanding of hematopoiesis and how this...

Overview:

Our laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat patients with leukemia, lymphoma, genetic blood disorders, and bone-marrow failure syndromes. We have expertise in utilizing...

The Bauer laboratory studies the genetic determinants of blood cell ontogeny and disease.

The lab uses molecular genetic, biochemical, and genome editing methodologies to perturb and observe blood cells. They are particularly interested in the role of...