In the Clinic

Our goal is to develop significant new treatments for diabetes. We aim to eliminate the present practice of regular blood checks and insulin injections, replacing them with insulin-producing cell transplants, specifically pancreatic beta cells that...

We are interested in unlocking new paradigms of normal blood development with the long-term aim of building better models of childhood blood diseases.  The process of blood formation changes over a lifetime: the blood stem cells formed in the embryo...

The Flynn lab  is focused on the exploration and discovery of how biopolymers like RNA and glycans work together to control cellular processes in the context of human disease.

Glycans regulate a myriad of essential cellular functions, especially in the...

Osteoporosis is a major public health problem in our aging population. Fragility fractures cause pain, lack of functional independence, and increased mortality. New therapeutic strategies are sorely needed to boost bone formation and cure osteoporosis. In...

Zuzana Totova's laboratory is group of physicians and scientists who are passionate about tackling important questions in cancer biology, and aim to improve outcomes for cancer patients. Their research focuses on genetics and epigenetics of blood cancers

The Ebert lab focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS).

In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that predict...

Mario Suva's research is focused on the biology of brain tumors, in particular diffuse high-grade gliomas in adults and children.

We dissect how cellular heterogeneity and plasticity contribute to tumor properties. We study primary human samples at...

Scott Armstrong studies the mechanisms of cancer development, focusing on leukemia. One major interest of this lab is the relationship between leukemia, normal hematopoietic stem cells and the various hematopoietic cells of origin of leukemia.

The...

Alessandra Biffi is actively involved in gene therapy trials for genetic diseases of childhood. Her research focuses on enhancing the efficacy of HSC-based therapeutic approaches for LSDs with severe nervous system involvement.

Hematopoietic stem cell...

Vik Khurana M.D. Ph.D. is the inaugural incumbent of the Tracy T. Batchelor Endowed Chair in Neurology at MassGeneral Brigham, Chief of the Movement Disorders Division at Brigham and Women's Hospital and Associate Professor of Neurology at Harvard