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Healthy stem cells generated from terminally ill patients with Pearson Marrow Pancreatic Syndrome

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Using a difficult laboratory technique, HSCI physician-researchers have isolated genetically healthy stem cells from patients with Pearson Marrow Pancreas Syndrome (PS), a generally fatal infant blood disorder with less than a hundred reported cases...

Step forward for rare blood disorder

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Red blood cells were successfully made via induced pluripotent stem cells from a Diamond-Blackfan anemia patient. Image: Daley lab, Boston Children’s For first time, iPS cells flag potential drug for blood disease By Nancy Fliesler Harvard Stem Cell...

How a child made scientists think of cytokines as knobs instead of switches

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Bone marrow from a young boy diagnosed with Diamond-Blackfan anemia (DBA) shows a reduced number of erythroid precursor cells. In this case, an unusual gene mutation in the hormone EPO was identified and found to cause the anemia. Photo courtesy of Ekrem...

New connection between metabolism and red blood cell development

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HSCI researchers identify mechanism with therapeutic potential for anemia Each tissue in the body has different requirements for metabolism, or how it uses energy to function — for example, a muscle needs different molecules to fuel a contraction compared...

A new signaling system for blood regeneration

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A group of researchers, led by HSCI Co-Director David Scadden, MD, has shown that bone cells pass packets of genetic material directly to bone progenitors, increasing blood production and stimulating the immune cells necessary to fight infection. Blood is...

Harvard University licenses technology to Alkem, aiming to treat ischemic injury and vascular diseases

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Novel delivery system for tissue-regenerative molecules enables local, sustained release for greater efficacy Alkem Laboratories Limited (Alkem) has signed a license agreement with Harvard University’s Office of Technology Development to develop and...

HSCI faculty member appointed the inaugural Regenerative Biology Endowed Chair at Boston Children’s Hospital

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Fernando Camargo recognized for pioneering scientific contributions and outstanding leadership Fernando Camargo, Ph.D., has been named as the inaugural Regenerative Biology Endowed Chair by the Boston Children’s Hospital (BCH) Department of Pediatrics, in...

First-line treatments for myelodysplastic syndrome may trigger an oncogene

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By Alice McCarthy A recent paper published in New England Journal of Medicine reveals that treatment of myelodysplastic syndrome (MDS) with hypomethylating agents (HMAs) activates a sleeping oncogene, leading to poorer survival. This discovery raises the...

A new way to target resistant cancer

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Harvard researchers target chemotherapy-resistant leukemia by using metabolism By Jessica Lau Blood cancers like leukemia can be effectively treated with chemotherapy, but relapse usually occurs, due to resistant cancer cells that evade the original drug...

HSCI scientist awarded grant to develop gene therapy for HIV

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HSCI co-director David Scadden is part of a multi-institutional, cross-disciplinary team that has been awarded a $14.6 million grant from the National Institutes of Health. The team is using gene and cell therapy approaches to develop a potential cure for...

Missed signals: A new source of biological variation

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HSCI scientists find that signaling defects can influence red blood cell traits The field of genetics has made huge strides over the past couple of decades, from the first sequencing of the human genome to a growing understanding of the machinery that...

A solid vaccine for liquid tumors

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Biomaterial-based vaccine protects against acute myeloid leukemia in mice Acute myeloid leukemia (AML), a blood cancer that originates in the bone marrow has been treated with chemotherapy for over 40 years. While the treatment does often cause the cancer...