Kidney Disease

Combination of 3D bioprinting and stem cell-based tissue engineering could enable new approaches to treating chronic kidney disease A newly launched startup is building on innovations developed over several years at the Wyss Institute for Biologically...

Two HSCI researchers will receive the National Institutes of Health (NIH) Director's New Innovator Award. Jason Buenrostro, Ph.D. and Ryuji Morizane, M.D., Ph.D. have been recognized for their highly innovative biomedical research that has transformative...

Method for growing kidney organoids under flow enhances their vascularization and maturation, increasing their potential for drug testing and regenerative medicine Mini-organs, called organoids, are grown in a culture dish. They contain many of the cell...

Research identifies key factor leading to cell cycle arrest and fibrosis production in the kidney A new study of how scar tissue is produced in the kidneys has identified potential culprits and promising targets for intervention. The study, published in...

Mini-kidney organoid (2 mm dimaeter) grown from pluripotent stem cells. Harvard Stem Cell Institute (HSCI) researchers at Brigham and Women’s Hospital (BWH) have combined cutting-edge, gene-editing techniques with stem cell science to for the first time...

Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity. Photo courtesy of Ryuji Morizane. New technique...

FDA-approval required before clinical use A new blood test has the potential to reveal whether a person recently diagnosed with type 1 diabetes is already at risk for kidney failure—information that might allow physicians to alter the course of treatment...

Harvard stem cell researchers have successfully coaxed stem cells to become kidney tubular cells, a significant advance toward one day using regenerative medicine, rather than dialysis and transplantation, to treat kidney failure. The findings are...

It has long been a given that adult humans — and mammals in general — lack the capacity to grow new nephrons, the kidney’s delicate blood filtering tubules, which has meant that dialysis, and ultimately kidney transplantation, is the only option for the...

Harvard Stem Cell Institute (HSCI) scientists have identified a new therapeutic approach for treating polycystic kidney disease (PKD), one of the most common life threatening, inherited diseases in humans, affecting more than 1 in 500 individuals...