Cardiovascular Disease

By Alice McCarthy A research collaborative led by scientists at the Harvard Stem Cell Institute and Massachusetts General Hospital in Boston discovered that exercise restarts an aged heart’s ability to make new heart cells, a process that usually ends by...

Since their development more than a decade ago, brain organoids — brain-like structures grown in petri dishes from human stem cells — have helped scientists better understand a range of neurological disorders, including schizophrenia, epilepsy, and autism...

Novel delivery system for tissue-regenerative molecules enables local, sustained release for greater efficacy Alkem Laboratories Limited (Alkem) has signed a license agreement with Harvard University’s Office of Technology Development to develop and...

Bioengineered device offers insights into artificial muscular pumps, a step toward building an artificial heart Harvard University researchers, in collaboration with colleagues from Emory University, have developed the first fully autonomous biohybrid...

Researchers at Massachusetts General Hospital (MGH) led by Harvard Stem Cell Institute Principal Faculty Harald C. Ott M.D. have generated the embryonic cells that support early heart development. In their study, published in Nature Communications, these...

HSCI researchers show the healing mechanisms of extracellular vesicles using a heart-on-a-chip Extracellular vesicles (EVs) — nanometer-sized packages that travel between cells to deliver cues and cargo — are promising tools for the next generation of...

HSCI researchers create a detailed guide of the vital organ that may help personalize treatments HSCI researchers are part of a cross-institutional team of scientists that has created a detailed cellular and molecular map of the healthy human heart. Their...

HSCI researchers reverse heart failure in mice HSCI researchers have successfully tested a gene therapy in mice for Barth syndrome, a rare disease that can cause life-threatening heart failure. Published in the journal Circulation Research, the study...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a leading cause of sudden death from cardiac arrest in children and young adults. Marked by racing, irregular heartbeats, the inherited arrhythmia is typically silent until a child suddenly...

Research in the Harvard Stem Cell Institute (HSCI) Cardiovascular Disease Program centers on ten laboratories at Harvard University and its eight affiliated hospitals. Their shared goal is to develop new treatments for heart disease. “We’re interested in...