Blood Diseases

By Alice McCarthy A recent paper published in New England Journal of Medicine reveals that treatment of myelodysplastic syndrome (MDS) with hypomethylating agents (HMAs) activates a sleeping oncogene, leading to poorer survival. This discovery raises the...

Fernando Camargo recognized for pioneering scientific contributions and outstanding leadership Fernando Camargo, Ph.D., has been named as the inaugural Regenerative Biology Endowed Chair by the Boston Children’s Hospital (BCH) Department of Pediatrics, in...

Novel delivery system for tissue-regenerative molecules enables local, sustained release for greater efficacy Alkem Laboratories Limited (Alkem) has signed a license agreement with Harvard University’s Office of Technology Development to develop and...

A group of researchers, led by HSCI Co-Director David Scadden, MD, has shown that bone cells pass packets of genetic material directly to bone progenitors, increasing blood production and stimulating the immune cells necessary to fight infection. Blood is...

HSCI researchers identify mechanism with therapeutic potential for anemia Each tissue in the body has different requirements for metabolism, or how it uses energy to function — for example, a muscle needs different molecules to fuel a contraction compared...

HSCI scientists find that signaling defects can influence red blood cell traits The field of genetics has made huge strides over the past couple of decades, from the first sequencing of the human genome to a growing understanding of the machinery that...

HSCI co-director David Scadden is part of a multi-institutional, cross-disciplinary team that has been awarded a $14.6 million grant from the National Institutes of Health. The team is using gene and cell therapy approaches to develop a potential cure for...

Harvard researchers target chemotherapy-resistant leukemia by using metabolism By Jessica Lau Blood cancers like leukemia can be effectively treated with chemotherapy, but relapse usually occurs, due to resistant cancer cells that evade the original drug...

HSCI scientists develop CRISPR-based tool for lineage tracing A new mouse model allows scientists to track every cell in the body, from the embryo stage until adulthood. The system, published in the journal Cell, could yield a greater understanding of...

HSCI principal faculty member Stuart Orkin, M.D. is the recipient of the 2020 Harrington Prize for Innovation in Medicine. The award, established in 2014 by the Harrington Discovery Institute and the American Society for Clinical Investigation (ASCI)...