Nervous System Diseases Program

Just a few thousand neurons orchestrate evolutionarily advanced forelimb and digit dexterity. By Alice McCarthy One of the critical elements guiding the evolutionary advancement of brains, especially as brains have become super capable in mammals, is how...

A single-cell analysis of 3D models of the human cerebral cortex suggests they can be used to study important brain processes that have been difficult to investigate Adapted from the Broad Institute By Allessandra DiCorato Organoids are carefully grown...

New discoveries about the role of alpha-synuclein, a well-known protein marker of Parkinson’s, may provide insights for treatment for the disease One of the hallmarks of Parkinson’s disease (PD) is the accumulation in the brain of a protein known as alpha...

Since their development more than a decade ago, brain organoids — brain-like structures grown in petri dishes from human stem cells — have helped scientists better understand a range of neurological disorders, including schizophrenia, epilepsy, and autism...

Harvard and Broad researchers use 3D, miniature models of the human brain to advance disease understanding By Jessica Lau Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a...

Harvard and MIT researchers identify possible mechanism linking autism and intestinal inflammation Many people with autism spectrum disorders also experience unusual gastrointestinal inflammation, but thus far scientists have not established whether and...

2022 HSCI Nervous System Disease Program Request for Proposals on Vision Repair and Regeneration AWARD AMOUNT Trainee Awards will be made in amounts of up to $75,000 total funding per year. Faculty Awards will be made in amounts of up to $150,000 total...

HSCI researchers led by Tracy Young-Pearse, Ph.D., have developed a method to examine living brain cells and predict the rate of Alzheimer’s disease progression and cognitive decline. A new brain model has been developed that will allow patient-specific...

HSCI researchers use patient-derived motor neurons to screen for clinically relevant targets Harvard Stem Cell Institute (HSCI) researchers led by Clifford Woolf, M.D., Ph.D., have developed a high-throughput platform for discovering drug targets to treat...

Harvard and Broad researchers combine single-cell genomic technologies to map the mouse cortex Researchers at Harvard University and the Broad Institute of MIT and Harvard have created the first detailed atlas of a critical region of the developing mouse...