The Mulligan laboratory continues to be interested in the development of methods for the introduction of genes into mammalian cells, and the application of those methods in a numbers of areas of biology and medicine. Over the past few years, the...
Our group is working on cancer genetics, using the zebrafish genetic system to clarify developmental pathways subverted in human leukemias and solid tumors. The zebrafish animal model provides a powerful system for genetic analysis of vertebrate...
Our laboratory is interested in how immune responses in skin are initiated, and how T cell mediated memory responses occur in skin, and in particular a newly described population of antigen experienced T cells known as Resident Memory T Cell (TRM). We...
The muscular dystrophies are progressive disorders of striated muscle leading to breakdown of muscle integrity. Underlying this clinical presentation there is considerable genetic heterogeneity with the X-chromosomal recessive Duchenne and Becker forms...
The primary interest of our laboratory is to understand the cellular and molecular regulatory mechanisms leading to the establishment of the mammalian kidney using the mouse as a model system.
The kidney is made up of approximately one million functional...
The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney injury and repair and to translate this knowledge into new therapeutic strategies to treat patients suffering from kidney disease. We use mouse genetics...
My laboratory studies how atherosclerosis—narrowing and hardening of the arteries—occurs. Atherosclerosis leads to abnormalities in blood vessels and eventually affects the flow of blood. When atherosclerosis occurs in the arteries that supply blood to...