Overview:
Our laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat patients with leukemia, lymphoma, genetic blood disorders, and bone-marrow failure syndromes. We have expertise in utilizing...
We study human biology. Specifically, our current research is focused on the imaging and quantitative measurement of cancer biology and its treatment in vivo. My laboratory employs a variety of techniques including whole body and intravital microscopic...
The research interests of the Verdine lab lie in the emerging area of chemical biology. We study biologic processes underlying growth and proliferation of human cancer cells, control of gene expression, and preservation of genomic integrity. Our...
As a surgeon-scientist in the field of Pediatric Surgery and Transplantation Surgery, my major areas of investigation and interest began with two specific diseases that are highly lethal in children; namely congenital diaphragmatic hernia and congenital...
Michael J. Sandel is the Anne T. and Robert M. Bass Professor of Government at Harvard University, where he has taught political philosophy since 1980. His publications include Liberalism and the Limits of Justice (Cambridge University Press, 1982, 2nd...
Our research aims to understand the role of long intergenic non-coding RNAs (lincRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer. To further explore how lincRNAs may...
Metastatic cancers are the major reason for treatment failure in the clinic, but we lack a detailed understanding of how primary tumors metastasize, why these secondary tumors are relatively drug resistant, and what enables cancer cells to remain dormant...
Our research group focuses on methods spanning the laboratory to the laptop that are designed to use genomic and computational approaches to reveal the underlying biology. In particular, we have been looking at patterns of gene expression in cancer with...
Dr. Notarangelo's research focuses of the characterization of the molecular and cellular bases of congenital immunodeficiencies as illustrated through the study of human patients and of suitable animal models. In particular, his lab is actively involved...
Our goal is to understand how naturally occurring human genetic variation protects (or predisposes) some people to cardiovascular and metabolic disease—the leading cause of death in the world—and to use that information to develop therapies that can...