Diabetes

Our goal is to develop significant new treatments for diabetes. We aim to eliminate the present practice of regular blood checks and insulin injections, replacing them with insulin-producing cell transplants, specifically pancreatic beta cells that...

The Kulkarni laboratory investigates the signaling patwhays that promote growth and proliferation of islet cells, hormone-producing cells that are affected in type 1 and type 2 diabetes.

The Kulkarni lab is exploring the significance of growth factor...

The Zhang laboratory aims to apply their fundamental discoveries in epigenetics to studies of human diseases.

Research in Yi Zhang's laboratory is focused on epigenetic modifications, particularly DNA methylation and covalent histone modifications, which...

Dr. Gordon Weir has combined a career of caring for patients with diabetes with an intensive research focus on beta-cell replacement therapy.

One of the most important goals of diabetes research is to find sources of new beta cells (the islet cells in...

The Tseng laboratory investigates the mechanisms underlying the regulation of energy balance to develop potential therapies for combating obesity and related diseases.

Obesity is an epidemic health problem worldwide, which results from an imbalance...

The Mathis lab studies T cell differentiation and tolerance/autoimmunity, translating mechanistic studies on mouse models to normal and diseased humans.

Research on T cell differentiation in the Mathis group focus on maturation and selection of the T...

Richard T. Lee's laboratory seeks to understand heart failure and metabolic diseases that accompany human aging, and to translate that understanding into therapies, including stem cell transplantation strategies and new biological agents.

The Lee...

Susan Bonner-Weir investigates how the pancreatic beta cell changes with age and in response to challenges.

With a series of rodent models, Dr. Bonner-Weir has provided compelling evidence that adult pancreatic beta-cell mass increases in response to a...