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Discovery of sugar-coated RNA molecules opens up new area of cell biology

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Cells in our body bristle with sugars known as glycans that other cells can recognize via specialized receptors. By attaching to and modifying proteins and fats, glycans influence how proteins fold, how cues are sent between cells, and other cell-to-cell...

Gut-brain connection in autism

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Harvard and MIT researchers identify possible mechanism linking autism and intestinal inflammation Many people with autism spectrum disorders also experience unusual gastrointestinal inflammation, but thus far scientists have not established whether and...

HSCI receives grant from the Crown Prince of Abu Dhabi to help advance type 1 diabetes research

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Douglas Melton, Co-Director of the Harvard Stem Cell Institute (HSCI), has received a financial grant from His Highness Sheikh Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi. The grant will bolster HSCI research focusing on accelerating gene...

Improving stem cell-derived pancreatic cells with genetic engineering

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HSCI scientists advance Type 1 diabetes therapy by protecting cells from immune attack and stress The stem cell-based approach to treating Type 1 diabetes (T1D) is successfully being tested in the clinic, using a transplant of stem cell-derived beta cells...

Engineered T cells can prevent the autoimmune reaction that leads to type 1 diabetes

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HSCI scientists show that engineered “5-module CAR” T cells target harmful T cells responsible for type 1 diabetes Researchers have engineered a specialized type of T cell that can specifically target and eliminate harmful T cells, particularly the...

HSCI scientist receives early-career award

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HSCI Principal Faculty member Jose Ordovas-Montanes has received an early-career award from the New York Stem Cell Foundation (NYSCF). He has been named a NYSCF – Robertson Investigator, which recognizes cutting-edge research with the potential to...

Immuno-engineering to Improve Immunotherapy (i3) Center launches

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Cancer immunologists and biological engineers at Harvard unite to fight therapy-resistant cancers A new NIH-funded Immuno-Engineering to Improve Immunotherapy (i3) Center at Harvard University sets out to create new anti-cancer immunotherapies using...

Gut microbiome influences ALS outcomes

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HSCI scientists identify gut-brain connection in ALS By Jessica Lau HSCI scientists have identified a new gut-brain connection in the neurodegenerative disease amyotrophic lateral sclerosis, or ALS. The researchers found that in mice with a common ALS...

Cell therapy for all

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Chad Cowan is on a quest for the universal donor, which would make cell therapy available to populations – not just individuals. Harvard scientist Chad Cowan aims to make off-the-shelf cellular products, and democratize access to new medicines. His lab is...

Assassinating cancer

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Mario Suva and Ramesh Shivdasani are tackling some of the toughest, meanest cancers to clear a path to better treatments. Suva and Shivdasani are using every approach in their arsenal to figure out what makes cancer cells arise from healthy tissue. Armed...

Epidemic of autoimmune diseases calls for action

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‘Any patient with any disease’

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Sana Biotechnology licenses innovative immune-silent stem cell technology developed though Harvard’s Blavatnik Biomedical Accelerator Protecting transplanted cells from immune attack is a serious challenge. As with any organ transplant, cell lines derived...