Harvard Medical School

The Pu laboratory studies the regulation of gene expression in heart development and heart failure with the goal of applying their new knowledge towards regenerative approaches to congenital and acquired heart disease.

Research in William T. Pu's...

Research in the Polyak laboratory is dedicated to the study of human breast cancer with the goal of dissecting tumor evolution and use this information to improve the clinical management of breast cancer patients. 

Main areas of interests are: (1) breast...

The Mulligan laboratory continues to be interested in the development of methods for the introduction of genes into mammalian cells, and the application of those methods in a numbers of areas of biology and medicine. Over the past few years, the...

The Mathis lab studies T cell differentiation and tolerance/autoimmunity, translating mechanistic studies on mouse models to normal and diseased humans.

Research on T cell differentiation in the Mathis group focus on maturation and selection of the T...

The MacRae lab is focused on understanding the genetic contribution to common cardiovascular disease using human studies and complementary high-throughput biology in the zebrafish.

Our lab is interested in the role of functional inputs such as mechanical...

Richard T. Lee's laboratory seeks to understand heart failure and metabolic diseases that accompany human aging, and to translate that understanding into therapies, including stem cell transplantation strategies and new biological agents.

The Lee...

The Langenau lab investigates how it is that tumors can be remade following conventional chemotherapeutic intervention, using zebrafish as a model.

Our research focuses on using the zebrafish to better understand human cancer and to develop novel...

The muscular dystrophies are progressive disorders of striated muscle leading to breakdown of muscle integrity. Underlying this clinical presentation there is considerable genetic heterogeneity with the X-chromosomal recessive Duchenne and Becker forms...

The goal of Jordan Kreidberg's research is to understand the genetic mechanisms of organogenesis, with a focus on the urogenital system.

The Kreidberg lab aims to:

• Understand the inductive mechanisms of early organ development;
• Define regulatory interactions...

The Kim Lab has pioneered the use of stem cell biology approaches for the study of adult lung progenitor cells and lung cancer.

Through a combination of mouse genetics and cell biology, Kim has developed tools to identify and characterize cells with...