Jose Cancelas is a MD, PhD, hematologist with a broad background in transfusion medicine, cell therapies, hematology, and stem cell biology. He is the executive director of the Connell and O’Reilly Cell Manipulations Core Facility at Dana Farber Cancer...
The Simoes-Costa lab focuses on decoding the molecular programs that orchestrate cell differentiation in the vertebrate embryo.
We employ functional genomics to characterize the gene regulatory circuits that control cell state transitions during...
Studying these disorders and finding effective therapies has been challenging...
We are interested in unlocking new paradigms of normal blood development with the long-term aim of building better models of childhood blood diseases. The process of blood formation changes over a lifetime: the blood stem cells formed in the embryo...
The Van Galen Laboratory studies normal and malignant hematopoiesis, with a focus on hematopoietic stem cell aging and the development of acute myeloid leukemia. Our projects span age-associated inflammatory pathways, targeted therapies for leukemia, and...
Osteoporosis is a major public health problem in our aging population. Fragility fractures cause pain, lack of functional independence, and increased mortality. New therapeutic strategies are sorely needed to boost bone formation and cure osteoporosis. In...
The Franklin laboratory is focused on understanding fundamental biological principles at the intersection of immunology and regenerative biology.
Currently, we study the role of immune cells in tissue building and rebuilding in the context of injury...
Intriguingly, some mammalian digit tips (including mouse and human children) can regenerate following amputation, demonstrating that mammals...
The Dou lab investigates the intersection of aging and cancer, with a particular emphasis on nuclear events. Their...