2010

Synthetic RNAs Leading to Real Changes in Reprogramming Strategies Key limiting factors in the utility and applicability of induced pluripotent stem cells (IPSCs) include the low efficiency of transformation and the potentially oncogenic factors that are...

WT1 Targets Provide Insights Into Kidney Development The Wilms' tumor suppressor 1 gene (WT1) is an important factor in development of the progenitors of the nephron, the basic structural and functional unit of the kidney, during kidney development. In...

One of These Things is Not Like the Other…and Provides Clues to Developmental Potential Since induced pluripotent stem (iPS) cells were first introduced just a few years ago, their equivalence to embryonic stem cells has not been entirely ascertained. In...

Approaching an Endgame? Telomerase Defects Shed Light on Pluripotency The telomere is the region of DNA at the end of chromosomes that protects them and allows replication to proceed to the end of the chromosome. At each DNA replication cycle, the...

Tumor Suppressor Genes DOK Lung Cell Growth Tumor suppressors are genes whose products act to control cell division. Disturbance of tumor suppressor gene function can have serious implications for the development of cancer. HSCI Principal Faculty member...

New Technique Helps Identify Leukemia Initiating Cells Acute promyelocytic leukemia (APL) is associated with the accumulation of promyelocyte cells in the bone marrow and blood. A majority of APL patients have a chromosomal translocation leading to the...

Harvard Stem Cell Institute NIH Training Grant Call for Graduate Student Trainee Applications DEADLINE: March 12, 2010, 5pm Overview: The Harvard Stem Cell Institute is now accepting applications for one (1) graduate student fellow position to be funded...

The general theory of cancer development holds that malignancies occur because of the presence of certain genetic elements within the affected cells. But a new study by Harvard researchers at Massachusetts General Hospital (MGH) indicates that “good”...

Acute myelogenous leukemia (AML) is one of the most common types of leukemia—a cancer of the bone marrow and blood—in adults, affecting about 13,300 women and men in the United States annually. The disease is also diagnosed in hundreds of children in this...