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Making old hearts younger - HSCI researchers find protein that reverses some effects of aging in mice

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Two Harvard Stem Cell Institute (HSCI) researchers — a stem cell biologist and a practicing cardiologist at Brigham and Women’s Hospital — have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the...

The new potential of patient-specific blood vessel cells

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In a scientific first, HSCI scientists have successfully grown the cells that line the blood vessels—called vascular endothelial cells—from human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function. Using a unique...

Researchers generate protective embryonic heart cells

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Researchers at Massachusetts General Hospital (MGH) led by Harvard Stem Cell Institute Principal Faculty Harald C. Ott M.D. have generated the embryonic cells that support early heart development. In their study, published in Nature Communications, these...

Biohybrid fish made from human cardiac cells swims like the heart beats

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Bioengineered device offers insights into artificial muscular pumps, a step toward building an artificial heart Harvard University researchers, in collaboration with colleagues from Emory University, have developed the first fully autonomous biohybrid...

Harvard University licenses technology to Alkem, aiming to treat ischemic injury and vascular diseases

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Novel delivery system for tissue-regenerative molecules enables local, sustained release for greater efficacy Alkem Laboratories Limited (Alkem) has signed a license agreement with Harvard University’s Office of Technology Development to develop and...

Cyborg brain organoids offer insight into early brain development

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Since their development more than a decade ago, brain organoids — brain-like structures grown in petri dishes from human stem cells — have helped scientists better understand a range of neurological disorders, including schizophrenia, epilepsy, and autism...

Exercise may make old hearts younger

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By Alice McCarthy A research collaborative led by scientists at the Harvard Stem Cell Institute and Massachusetts General Hospital in Boston discovered that exercise restarts an aged heart’s ability to make new heart cells, a process that usually ends by...

A map of the human heart

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HSCI researchers create a detailed guide of the vital organ that may help personalize treatments HSCI researchers are part of a cross-institutional team of scientists that has created a detailed cellular and molecular map of the healthy human heart. Their...

Reviving cells after a heart attack

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HSCI researchers show the healing mechanisms of extracellular vesicles using a heart-on-a-chip Extracellular vesicles (EVs) — nanometer-sized packages that travel between cells to deliver cues and cargo — are promising tools for the next generation of...

Gene therapy for Barth syndrome

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HSCI researchers reverse heart failure in mice HSCI researchers have successfully tested a gene therapy in mice for Barth syndrome, a rare disease that can cause life-threatening heart failure. Published in the journal Circulation Research, the study...

Modified RNA offers drug-like approach to regenerating heart tissue

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Heart attacks cause the death of billions of the heart’s muscle cells. If these cardiomyocytes could be made to regenerate after an infarct, the heart could potentially be mended and its function restored. Researchers have struggled to find the right...

Long-lasting blood vessels generated from human iPS cells

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Harvard Stem Cell Institute researchers at Massachusetts General Hospital (MGH) succeeded in using reprogrammed human stem cells to make working blood vessels in mice that can survive for as long as nine months. The blood vessels were created with induced...