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215 results for "ALS"

215 results for "ALS"

ALS

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Harvard Stem Cell Institute scientists offer new hope for the 30,000 Americans living with a paralyzing and fatal disease with no known cause. New York Yankee first baseman Lou Gehrig was having a lousy season in 1939. Known for his record-number home...

Accelerating a treatment for ALS

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Clinical trial success based on stem cell models in the lab Summary A clinical trial, supported in part by the Harvard Stem Cell Institute (HSCI), has shown that the drug retigabine improves a characteristic of motor neurons that is impacted in...

The ALS challenge continues

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HSCI scientists are using stem cells to redefine what it means to study this deadly disease Professor Kevin Eggan was mid-sentence, discussing the importance of raising awareness for ALS research, when members of his lab dumped five buckets of freezing...

Potential therapeutic target for ALS

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Discovery opens doors to improving diagnostics and developing new therapy for majority of ALS patients Summary HSCI-funded research using human pluripotent stem cell models and tissue from ALS patients found that the protein TDP-43 regulates a gene called...

Gut microbiome influences ALS outcomes

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HSCI scientists identify gut-brain connection in ALS By Jessica Lau HSCI scientists have identified a new gut-brain connection in the neurodegenerative disease amyotrophic lateral sclerosis, or ALS. The researchers found that in mice with a common ALS...

HSCI researchers identify another potential ALS treatment

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Similar results in experimental animals and human cells in dish A series of studies begun by Harvard Stem Cell Institute (HSCI) scientists eight years ago has led to a report, published in Science Translational Medicine, that may be a major step forward...

Class of 1989 honors classmate with ALS fund

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This year, the Harvard College Class of 1989 established a fund around its 20th Reunion for its classmate Jack Orchard, who was stricken with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. The class raised over $100, 000 for stem...

Patient stem cells help identify common problem in ALS

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Discovery will lead directly to clinical trials Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)—Lou Gehrig’s disease, a uniformly...

Research suggests new avenues for attacking ALS

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In the spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid...

Another step forward in ALS and stem cell research

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A Harvard Stem Cell Institute research team has succeeded in deriving spinal motor neurons from human embryonic stem cells, and has then used them to replicate the Amyotrophic Lateral Sclerosis (ALS) disease process in a laboratory dish. The researchers...