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Harvard stem cell scientists have a new theory for how stem cells decide whether to become liver or pancreatic cells during development. A cell’s fate, the researchers found, is determined by the nearby presence of prostaglandin E 2, a messenger molecule...

Harvard stem cell scientists studying the effect of nitric oxide on liver growth and regeneration appear to have serendipitously discovered a markedly improved treatment for liver damage caused by acetaminophen toxicity—the cause of half the U.S. hospital...

Harvard Stem Cell Institute (HSCI) researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity. The gene, SALL4, gives...

Two studies by HSCI scientists advance our understanding of cancer Two new studies by Harvard Stem Cell Institute (HSCI) scientists give important insights into lung and liver cancers, and have potential implications for cancer treatment. Carla Kim, Ph.D...

Research identifies key factor leading to cell cycle arrest and fibrosis production in the kidney A new study of how scar tissue is produced in the kidneys has identified potential culprits and promising targets for intervention. The study, published in...

When the Hippo pathway is inactivated, mature liver cells revert back to a stem cell-like state. Picture shows a group of cells transitioning from a mature cell type (green) to a stem cell type (red). White cells are the cells where Hippo is being...