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Yu-Hua Tseng, Ph.D.

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The Tseng laboratory investigates the mechanisms underlying the regulation of energy balance to develop potential therapies for combating obesity and related diseases.

Obesity is an epidemic health problem worldwide, which results from an imbalance...

Vital genes in fat production found

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Above, human brown fat progenitor cells express the calorie-burning, UCP1 proteins (green) as the cell differentiates. (Tseng Laboratory, Joslin Diabetes Center) Harvard Stem Cell Institute (HSCI) scientists at Harvard-affiliated Joslin Diabetes Center...

Seed Grants 2009

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Program Lead Affiliation Title Disease Area Wolfram Goessling, MD, PhD and Trista E. North, PhD Brigham and Women's Hospital and Beth Israel Deaconess Medical Center Isolating novel regulators of liver regeneration through a chemical genetic modifier...

Pain receptors are linked to the generation of energy-burning fat cells

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HSCI researchers identify new potential target for obesity therapy Harvard Stem Cell Institute (HSCI) researchers have uncovered a new source of energy-burning brown fat cells, which points toward potential new therapeutic options for obesity. Published...

A promising cell therapy for obesity and diabetes

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HSCI scientists show proof of concept that transplanted brown-fat-like cells can treat metabolic diseases Harvard Stem Cell Institute scientists have developed a proof of concept for a novel cell-based therapy against obesity, the main cause of type 2...

2009 HSCI Seed Grant Recipients Announced

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For the fifth consecutive year, HSCI awarded seed grants to scientists throughout the Harvard community to provide critical early funding for stem cell research. In May, eight seed grants totaling nearly $1.5 million were awarded to investigators selected...

Lung diseases in mice reversed by coaxing production of healthy cells

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Harvard stem cell researchers have shown that it may one day be possible to treat several lung diseases by introducing proteins that direct lung stem cells to grow the specific cell types needed to repair the lung injuries involved in the conditions...

HSCI funds two translational junior faculty projects

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Many tissues and organs in our bodies have a remarkable capacity to regenerate in response to injury or disease. If we slice our finger, for instance, our blood replenishes and our skin heals; we can even donate a section of our liver and it will quickly...

Junior Faculty Programs

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HSCI's Junior Faculty Programs have focused on the following areas: Regulation of Immune Privilege and Autoimmunity (2018- ~2021) The overall project goal is to identify extrinsic and intrinsic mechanisms that regulate stem cells' sensitivity to...

Media Mentions 2017

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December 2017 12/18/17 A Wall Street Journal video highlights Harald Ott’s work on organ regeneration. 12/16/17 In an article by The Guardian , James Gusella comments on the potential of gene therapy to treat Huntington’s disease. 12/7/17 An article by...

Seed Grant Awards

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Fall 2021 Collaborative Seed Grant Recipients Project Lead Collaborating PI Affiliation Title Research Area Yingzi Yang, PhD Jennifer Gibbs, DDS, PhD Harvard School of Dental Medicine Sensory nerve regulation of dentin repair in molars Dental diseases...

Faculty

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HSCI is a network of over 350 faculty across Harvard who are harnessing the power of stem cells to find new treatments and cures for disease. HSCI has been breaking down barriers to collaboration in stem cell science since 2004. We have been instrumental...