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Alzheimer's Disease

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Eventually, Alzheimer’s kills, but not before it takes everything away from you. —Alzheimer’s Association A longer lifespan comes with a catch; an increase in the percentage of the population living into advanced old age brings with it a sharp increase in...

$1 million gift supports stem cell research on Alzheimer’s disease

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Ever since the 2004 founding of the Harvard Stem Cell Institute, the vision and generosity of individual donors has been and continues to be our largest and most stable source of support. The Institute was launched with a major challenge grant from a...

New brain model sheds patient-specific light on Alzheimer’s disease

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HSCI researchers led by Tracy Young-Pearse, Ph.D., have developed a method to examine living brain cells and predict the rate of Alzheimer’s disease progression and cognitive decline. A new brain model has been developed that will allow patient-specific...

Alzheimer’s in a dish

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Stem cells from patients offer model and drug-discovery platform for early-onset form of disease Harvard stem cell scientists have successfully converted skin cells from patients with early-onset Alzheimer’s into the types of neurons that are affected by...

Alzheimer’s in 3-D

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New culture system makes it possible to observe progression of plaques and tangles Massachusetts General Hospital (MGH) scientists, in collaboration with Harvard Stem Cell Institute (HSCI) researchers, have developed a three-dimensional laboratory culture...

Alzheimer’s Drug Discovery Foundation funds research into drugs mimicking the neuroprotective effects of exercise

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By Alice McCarthy Physical activity, especially endurance exercise, can improve cognitive function in part by reducing neuroinflammation. Research from HSCI affiliate member Christiane Wrann has shown that the hormone irisin, which is secreted from...

HSCI Disease Program Seminar Series

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Register by clicking here. Presenters: Vicky Chou, Graduate student, Young-Pearse Lab, BWH Understanding the role of SHIP1 in Alzheimer's disease using iPSC-derived Microglia-like Cells Hyo Lee, Graduate student, Young-Pearse Lab, BWH Establishing iPSC...

Alzheimer's at the level of single cells

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Young-Pearse and colleagues studied human astrocytes (red) and neurons (green) derived from iPS cells. Photo courtesy of Sarah Sullivan. Study of plaque production holds promise for improved treatments By B.D. Colen, HSCI Director of Communications...

The hormone irisin is found to confer benefits of exercise on cognitive function

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New insight into the workings of the hormone irisin shows it has the ability to spur the cognitive benefits of exercise, holding promise for treating cognitive decline in Alzheimer's disease, a HSCI led team at Massachusetts General Hospital have found...

Disease Brochures

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Stem cell science holds promise for a range of injuries and genetic diseases. The brochures (PDFs) below summarize HSCI's programs to target and cure disease. Research Projects on Aging Amyotrophic Lateral Sclerosis (ALS) Alzheimer's Disease Cancer Using...

Nervous System Diseases Program

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Scientists in the HSCI Nervous System Diseases Program investigate neurodegenerative and traumatic diseases of the brain and spinal cord. Their goal is to understand exactly which neurons degenerate and why, and how to interfere with the degenerative...

HSCI scientist receives awards to study Parkinson’s Disease

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HSCI Principal Faculty member Vikram Khurana has received three awards to advance his innovative research on Parkinson’s disease, a neurodegenerative disorder that impacts millions of patients around the world. Khurana is a winner of the “ Ken Griffin...