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Lung diseases in mice reversed by coaxing production of healthy cells

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Harvard stem cell researchers have shown that it may one day be possible to treat several lung diseases by introducing proteins that direct lung stem cells to grow the specific cell types needed to repair the lung injuries involved in the conditions...

HSCI scientist receives award for lung cancer research

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HSCI Executive Committee member Carla Kim is a recipient of the Lung Cancer Discovery Award from the American Lung Association. The award recognizes Kim’s innovative lung cancer research that has the potential to improve patient care and help save lives....

Jayaraj Rajagopal, MD

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The Rajagopal lab focuses on organ regeneration and the application of developmental biology to human disease. They utilize the lung as a model system, in part due to the abundance of respiratory diseases of unknown causes and without cures.

The lung is...

3D Organoids to Model Diseases

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A few examples of the exciting work by HSCI scientists in developing organoids to deepen our understanding of diseases: https://hsci.harvard.edu/news/long-cultured-organoids-open-new-vistas-b… Brain Organoids: Long-cultured organoids...

Lung and liver cancers: new findings

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Two studies by HSCI scientists advance our understanding of cancer Two new studies by Harvard Stem Cell Institute (HSCI) scientists give important insights into lung and liver cancers, and have potential implications for cancer treatment. Carla Kim, Ph.D...

A major step toward a treatment for cystic fibrosis HSCI researchers create lung surface tissue in a dish

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HSCI researchers at Massachusetts General Hospital have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1000...

Carla F. Kim, Ph.D.

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The Kim Lab has pioneered the use of stem cell biology approaches for the study of adult lung progenitor cells and lung cancer.

Through a combination of mouse genetics and cell biology, Kim has developed tools to identify and characterize cells with...

3D organoids and RNA sequencing reveal the crosstalk driving lung cell formation

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By Nancy Fleisler ( Boston Children's Hospital) and Javier Barbuzano (Harvard Stem Cell Institute) To stay healthy, our lungs have to maintain two key populations of cells: the alveolar epithelial cells, which make up the little sacs where gas exchange...

Organoids: A new window into disease, development and discovery

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Scientists have found ways of culturing organ-specific tissue from stem cells that could change the way diseases are studied and treated. By Javier Barbuzano Imagine the possibility of creating individualized, complex collections of cells that bear a...

Two HSCI Principal Faculty receive international recognition

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Adapted from an ISSCR press release For the second year in a row, the International Society for Stem Cell Research (ISSCR) recognized two HSCI Principal Faculty members at the ISSCR Annual Meeting for their outstanding contributions to the stem cell...

Big advance against cystic fibrosis

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Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step toward discovering in the relatively near future a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1...

A deeper understanding of cystic fibrosis

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Researchers find a new type of lung cell involved in cystic fibrosis By Jessica Lau In cystic fibrosis, mucus builds up in the lungs and leads to breathing difficulties because cells do not properly make the CFTR protein. Although scientists have known...