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Joseph V. Bonventre, M.D., Ph.D.

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The Bonventre lab studies renal cell carcinoma, focusing on the functional role of the protein 'Kidney injury molecule-1' as well as its role as a urinary biomarker for renal cell carcinoma and renal epithelial cell injury.

Joseph Bonventre has had a...

Making Mature Nephrons

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Using normal kidney development as a roadmap, HSCI Executive Committee member Joseph Bonventre and a team of researchers developed an efficient method to make human kidney precursor cells . The precursor cells self-assembled into organoids, which could be...

Kidney injury molecule linked to chronic kidney disease

News

More than 15 years after the discovery of kidney injury molecule-1 (KIM-1) by Joseph Bonventre, MD, PhD, researchers in the HSCI Kidney Disease Program—of which Bonventre is a member—have found that the molecule promotes the scar tissue formation...

Modeling genetic diseases in mini-kidney organoids

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Mini-kidney organoid (2 mm dimaeter) grown from pluripotent stem cells. Harvard Stem Cell Institute (HSCI) researchers at Brigham and Women’s Hospital (BWH) have combined cutting-edge, gene-editing techniques with stem cell science to for the first time...

Researchers identify first blood biomarker for progressive kidney disease

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FDA-approval required before clinical use A new blood test has the potential to reveal whether a person recently diagnosed with type 1 diabetes is already at risk for kidney failure—information that might allow physicians to alter the course of treatment...

Kidney fibrosis study reveals causes, potential therapeutic target

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Research identifies key factor leading to cell cycle arrest and fibrosis production in the kidney A new study of how scar tissue is produced in the kidneys has identified potential culprits and promising targets for intervention. The study, published in...

HSCI hosts Harvard-BI fibrosis network meeting

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Group photo at the semi-annual meeting of the joint steering committee of the HSCI’s collaboration with Boehringer Ingelheim in fibrosis research with the research project teams. This past week, Harvard Stem Cell Institute (HSCI) hosted the semi-annual...

Patient stem cells offer insight into origins of polycystic kidney disease

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Harvard Stem Cell Institute (HSCI) scientists have identified a new therapeutic approach for treating polycystic kidney disease (PKD), one of the most common life threatening, inherited diseases in humans, affecting more than 1 in 500 individuals...

Investigators create complex kidney structures from human stem cells derived from adults

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Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity. Photo courtesy of Ryuji Morizane. New technique...

HSCI researchers generate kidney tubular cells from stem cells

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Harvard stem cell researchers have successfully coaxed stem cells to become kidney tubular cells, a significant advance toward one day using regenerative medicine, rather than dialysis and transplantation, to treat kidney failure. The findings are...

Students selected for NIH training program

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In keeping with its mission to train future generations of stem cell scientists, HSCI’s Training Program supports graduate and postdoctoral students engaged in stem cell research in the laboratory of an HSCI principal faculty member. Now in its third year...

HSCI Executive Committee welcomes four new members

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HSCI encompasses some 900 scientists in laboratories across 11 Harvard-affiliated institutions. Guiding this large, complex enterprise is the responsibility of HSCI’s Executive Committee, which has played a pivotal role in positioning the institute as the...