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3D organoids and RNA sequencing reveal the crosstalk driving lung cell formation

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By Nancy Fleisler ( Boston Children's Hospital) and Javier Barbuzano (Harvard Stem Cell Institute) To stay healthy, our lungs have to maintain two key populations of cells: the alveolar epithelial cells, which make up the little sacs where gas exchange...

Genes protect themselves against being silenced

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Harvard Stem Cell Institute (HSCI) researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated. As explicated today in the...

An HSCI approach to rhabdomyosarcoma

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Rhabdomyosarcoma is a rare childhood cancer that arises in muscle stem cells. Between 250-350 cases are treated each year. The disease most commonly begins as a noticeable swelling in the arms, legs, head, neck, or groin, and is treated by surgical...

Engineered ‘off-the-shelf’ stem cells target breast cancer that metastasizes to the brain

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Harvard Stem Cell Institute (HSCI) researchers have engineered stem cells that can deliver a tumor-suppressing and killing molecule to the brain. They tested the therapy in three new mouse models of breast cancer that metastasizes to the brain, and found...

New connection between metabolism and red blood cell development

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HSCI researchers identify mechanism with therapeutic potential for anemia Each tissue in the body has different requirements for metabolism, or how it uses energy to function — for example, a muscle needs different molecules to fuel a contraction compared...

MicroRNAs and Hippo: Connected in cancer

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A Harvard Stem Cell Institute (HSCI) collaboration between a molecular chemist who studies microRNAs and a stem cell biologist interested in cell growth has led to new understanding of what goes wrong in several kinds of cancer. Boston Children’s Hospital...

A new study illuminates the therapy resistance of metastatic prostate cancer

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Bone metastases are devastating developments of cancers that originate in other organs. In the case of metastatic prostate cancer, bone metastases represent an incurable, painful, and often deadly development, killing more than 30,000 American men every...

A case of mistaken identity: HSCI researchers unmask cellular source of Barrett’s esophagus

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For most cells within the body, identity is non-negotiable: a bladder cell cannot impersonate a blood cell, and a liver cell remains a liver cell. One of the rare exceptions has been thought to be a condition known as Barrett’s esophagus, in which the...

Call for Proposals: 2022 HSCI Cancer Program Pilot Grants

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AWARD AMOUNT Up to $100,000 for entire project period Project period not to exceed 2 years POSTED DATE Wednesday, February 2, 2022 DEADLINE FOR APPLICATION Friday, March 4, 2022 ANTICIPATED AWARD DATE April 1, 2022 The Harvard Stem Cell Institute (HSCI)...

HSCI faculty member appointed the inaugural Regenerative Biology Endowed Chair at Boston Children’s Hospital

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Fernando Camargo recognized for pioneering scientific contributions and outstanding leadership Fernando Camargo, Ph.D., has been named as the inaugural Regenerative Biology Endowed Chair by the Boston Children’s Hospital (BCH) Department of Pediatrics, in...

Kara McKinley Receives NIH Director’s New Innovator Award

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Dr. McKinley will receive $1.5 million over five years to continue her work in uterine regeneration, focused on establishing an animal model of menstruation. By Alice McCarthy The NIH Director’s New Innovator Award recognizes career excellence among early...

Kara McKinley named Packard Fellow for Science and Engineering

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Kara McKinley, PhD, principal faculty at HSCI, has been named one of the 2022 class of Packard Fellows for Science and Engineering. McKinley and 19 other innovative early-career scientists and engineers will each receive $875,000 over five years to pursue...