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Genes protect themselves against being silenced

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Harvard Stem Cell Institute (HSCI) researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated. As explicated today in the...

Stem cells prepare early for differentiation

News
New data showing human embryonic stem cell gene expression and epigenetic activity (e.g., tagging DNA to silence specific genes) reveals that stem cells prepare early to differentiate into their next form. The research, led by HSCI Principal Faculty...

Mutation linked to male infertility

News
Harvard Stem Cell Institute (HSCI) researchers have found a link between male infertility and a mutation in a gene critical for sperm production. If the gene, Elongator Protein 1/Inhibitor of KappaB Kinase-associated Protein (Elp1/IKAP), is turned off...

Missed signals: A new source of biological variation

News
HSCI scientists find that signaling defects can influence red blood cell traits The field of genetics has made huge strides over the past couple of decades, from the first sequencing of the human genome to a growing understanding of the machinery that...

Mapping the epigenome

News
Ten years ago, scientists announced the end of the Human Genome Project, the international attempt to learn which combination of four nucleotides—adenine, thymine, cytosine, and guanine—is unique to homo sapien DNA. This biological alphabet helped...

A ‘volume control’ for pain

News
HSCI scientists identify a potential target for treating neuropathic pain Why do people with neuropathic pain feel pain from minor touches and other normally harmless stimuli? Setting out to answer this question, Harvard Stem Cell Institute (HSCI)...

Cell therapy for all

News
Chad Cowan is on a quest for the universal donor, which would make cell therapy available to populations – not just individuals. Harvard scientist Chad Cowan aims to make off-the-shelf cellular products, and democratize access to new medicines. His lab is...

Assassinating cancer

News
Mario Suva and Ramesh Shivdasani are tackling some of the toughest, meanest cancers to clear a path to better treatments. Suva and Shivdasani are using every approach in their arsenal to figure out what makes cancer cells arise from healthy tissue. Armed...

Reinventing painkillers

News
Clifford Woolf wants to reboot drug discovery to find a new way to treat pain: effectively and responsibly. Woolf’s goal is to stop the opioid crisis by rejecting the conventional approach to drug discovery and developing painkillers that do not harm...

HSCI-supported research leads to new class of therapeutics

News
Biotech company Moderna, co-founded by HSCI scientist Derrick Rossi, is set to bring a new class of treatments to patients. Summary Derrick Rossi’s research into using mRNA as a new kind of therapeutic was initially supported by HSCI seed funding, and...