Kevin Eggan

HSCI researchers use patient-derived motor neurons to screen for clinically relevant targets Harvard Stem Cell Institute (HSCI) researchers led by Clifford Woolf, M.D., Ph.D., have developed a high-throughput platform for discovering drug targets to treat...

HSCI scientists identify gut-brain connection in ALS By Jessica Lau HSCI scientists have identified a new gut-brain connection in the neurodegenerative disease amyotrophic lateral sclerosis, or ALS. The researchers found that in mice with a common ALS...

Discovery opens doors to improving diagnostics and developing new therapy for majority of ALS patients Summary HSCI-funded research using human pluripotent stem cell models and tissue from ALS patients found that the protein TDP-43 regulates a gene called...

Clinical trial success based on stem cell models in the lab Summary A clinical trial, supported in part by the Harvard Stem Cell Institute (HSCI), has shown that the drug retigabine improves a characteristic of motor neurons that is impacted in...

In a cross-school collaboration, Harvard researchers Steve McCarroll (left) and Kevin Eggan (right) couple stem cell science with genetics and genomics to advance our understanding of human brain illnesses. Their latest project identified mutations that...

Zika virus (light blue) spreads through a three-dimensional model of a developing brain. Image courtesy of Max Salick and Nathaniel Kirkpatrick/Novartis The fast-spreading virus can take multiple routes into developing human nerve cells. By Hannah Robbins...

In the spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid...

Above, one type of hypothalamic neuron created from stem cells. For the first time, researchers have access to these live human neuron types that are involved in everything from the regulation of sleep, to obesity, and other basic processes. A New Stem...

Turning skin cells into pain-sensing neurons Human noxious stimulus detecting sensory neurons produced by converting skin cells with a set of five genes to this new fate—enabling study of "pain"in a dish. (Credit: Elizabeth Buttermore, PhD) After more...

Similar results in experimental animals and human cells in dish A series of studies begun by Harvard Stem Cell Institute (HSCI) scientists eight years ago has led to a report, published in Science Translational Medicine, that may be a major step forward...