Joseph Bonventre

Combination of 3D bioprinting and stem cell-based tissue engineering could enable new approaches to treating chronic kidney disease A newly launched startup is building on innovations developed over several years at the Wyss Institute for Biologically...

Method for growing kidney organoids under flow enhances their vascularization and maturation, increasing their potential for drug testing and regenerative medicine Mini-organs, called organoids, are grown in a culture dish. They contain many of the cell...

Research identifies key factor leading to cell cycle arrest and fibrosis production in the kidney A new study of how scar tissue is produced in the kidneys has identified potential culprits and promising targets for intervention. The study, published in...

Boehringer Ingelheim today announced it has established a research collaboration with the Harvard Stem Cell Institute’s - Harvard Fibrosis Network to discover new ways of treating fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), chronic...

Mini-kidney organoid (2 mm dimaeter) grown from pluripotent stem cells. Harvard Stem Cell Institute (HSCI) researchers at Brigham and Women’s Hospital (BWH) have combined cutting-edge, gene-editing techniques with stem cell science to for the first time...

Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity. Photo courtesy of Ryuji Morizane. New technique...

FDA-approval required before clinical use A new blood test has the potential to reveal whether a person recently diagnosed with type 1 diabetes is already at risk for kidney failure—information that might allow physicians to alter the course of treatment...

Harvard stem cell researchers have successfully coaxed stem cells to become kidney tubular cells, a significant advance toward one day using regenerative medicine, rather than dialysis and transplantation, to treat kidney failure. The findings are...

Harvard Stem Cell Institute (HSCI) scientists have identified a new therapeutic approach for treating polycystic kidney disease (PKD), one of the most common life threatening, inherited diseases in humans, affecting more than 1 in 500 individuals...

More than 15 years after the discovery of kidney injury molecule-1 (KIM-1) by Joseph Bonventre, MD, PhD, researchers in the HSCI Kidney Disease Program—of which Bonventre is a member—have found that the molecule promotes the scar tissue formation...