Kidney Diseases Program

Combination of 3D bioprinting and stem cell-based tissue engineering could enable new approaches to treating chronic kidney disease A newly launched startup is building on innovations developed over several years at the Wyss Institute for Biologically...

Two HSCI researchers will receive the National Institutes of Health (NIH) Director's New Innovator Award. Jason Buenrostro, Ph.D. and Ryuji Morizane, M.D., Ph.D. have been recognized for their highly innovative biomedical research that has transformative...

Research identifies key factor leading to cell cycle arrest and fibrosis production in the kidney A new study of how scar tissue is produced in the kidneys has identified potential culprits and promising targets for intervention. The study, published in...

Mini-kidney organoid (2 mm dimaeter) grown from pluripotent stem cells. Harvard Stem Cell Institute (HSCI) researchers at Brigham and Women’s Hospital (BWH) have combined cutting-edge, gene-editing techniques with stem cell science to for the first time...

Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity. Photo courtesy of Ryuji Morizane. New technique...

Harvard Stem Cell Institute (HSCI) scientists have identified a new therapeutic approach for treating polycystic kidney disease (PKD), one of the most common life threatening, inherited diseases in humans, affecting more than 1 in 500 individuals...

More than 15 years after the discovery of kidney injury molecule-1 (KIM-1) by Joseph Bonventre, MD, PhD, researchers in the HSCI Kidney Disease Program—of which Bonventre is a member—have found that the molecule promotes the scar tissue formation...

Harvard Stem Cell Institute (HSCI) researchers have a new model for how the kidney repairs itself, a model that adds to a growing body of evidence that mature cells are far more plastic than had previously been imagined. After injury, mature kidney cells...