Musculoskeletal Diseases

Osteoporosis is a major public health problem in our aging population. Fragility fractures cause pain, lack of functional independence, and increased mortality. New therapeutic strategies are sorely needed to boost bone formation and cure osteoporosis. In...

The Lehoczky lab is anchored in thinking about why mammals do not regenerate their limbs following amputation.

Intriguingly, some mammalian digit tips (including mouse and human children) can regenerate following amputation, demonstrating that mammals...

The Rosen lab seeks to understand the molecular mechanisms underlying musculoskeletal diseases.

Bone Morphogenetic Proteins (BMPs) are a family of secreted signaling molecules that transmit information between cells. All cells have BMP receptors and BMP...

April Craft’s lab studies the development of cartilage and other synovial joint tissues, with hopes of applying this knowledge toward the development of therapeutics for disease attenuation and tissue regeneration and repair.

To achieve this goal, they...

Yingzi Yang's research has bridged discoveries of fundamental mechanisms with the characterization and treatment of diseases including severe birth defects, osteoporosis, osteoarthritis and heterotopic bone formation.

The Yang lab uses molecular...

The Pourquié laboratory is a world leader in vertebrate musculo-skeletal axis development.

We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and...

Amy Wagers seeks to change the way we repair our tissues after an injury. 

Her research focuses on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.

S...

The Langenau lab investigates how it is that tumors can be remade following conventional chemotherapeutic intervention, using zebrafish as a model.

Our research focuses on using the zebrafish to better understand human cancer and to develop novel...

The Galloway lab aims to apply new discoveries to developing regenerative biology solutions that can better heal and repair tendon and ligament injuries.

Injuries to tendons and ligaments result in a slow, imperfect regenerative response. In most cases...