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X-WR-CALNAME;VALUE=TEXT:CRISPR-Cas System and the Future of Genome Editing
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SUMMARY:CRISPR-Cas System and the Future of Genome Editing
DESCRIPTION:<p><span style="color: #68a7bb;"><strong>Course Description</strong></span><br>Clustered regularly interspaced short palindromic repeat (CRISPR) RNAs and their CRISPR-associated (Cas) proteins are an important part of adaptive immune systems in many prokaryotes. CRISPR-Cas systems function as RNA-directed endonucleases that can target nucleic acids in a sequence-specific manner and are now widely used as genome editing tools. In this course, we will provide lectures covering: an introduction to genome editing and cutting-edge improvements to CRISPR-Cas systems; a review of bioinformatics tools for guide RNA design and analysis of CRISPR-Cas data; and an overview of on-going and potential therapeutic applications of genome-editing nucleases. The course will also include a practical lab-based workshop for registered students in which participants will learn how to design guide RNAs and how to perform the broadly useful TIDE assay that enables quantification of nuclease-induced mutations in any cell or organism.<br> <br><span style="color: #68a7bb;"><strong>Nanocourse Director:</strong></span> J. Keith Joung<br><span style="color: #68a7bb;"><strong>Curriculum Fellow:</strong></span> Emily Gleason (<a href="mailto:emily_gleason@hms.harvard.edu">emily_gleason@hms.harvard.edu</a>)<br> <br><strong><span style="color: #68a7bb;">Lecturers</span></strong><br>•    <em><strong>J. Keith Joung, MD, PhD</strong></em>, Professor of Pathology, Harvard Medical School and Pathologist, Massachusetts General Hospital<br>•    <em><strong>Luca Pinello, PhD</strong></em>, Instructor in Medicine, Massachusetts General Hospital Department of Pathology<br>•    <em><strong>Morgan Maeder, PhD</strong></em>, Scientist, Editas Medicine<br> <br> </p>
LOCATION:Harvard Medical School, Armenise Amphitheater, 210 Longwood Avenue, Boston, MA
STATUS:CONFIRMED
DTSTART:20161110T143000Z
DTEND:20161110T180000Z
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