HSCI Cancer Disease Program Leaders Carla F. Kim, PhD and Mario Suva, MD, PhD, and HSCI Skin Disease Program Leaders Markus Frank, MD and George F. Murphy, MD have planned an exciting 2-day symposium, including talks by leading researchers from our community and other institutions including keynotes from Robert M. Lavker, PhD and Irving Weissman, MD.
The HSCI Cancer Program will be featured as first day of a two days Symposium and will be followed by the HSCI Skin Program. The HSCI Cancer Program will cover the evolution of the stem cell model of cancer through the lens of state-of-art technologies such as single-cell multi-omics and epigenomics. We will discuss metabolic dependencies of malignant stem cells and their specific interactions with the immune system. The symposium will feature speakers and posters selected from abstracts.
The HSCI Skin Program brings together local expertise and national prominence in skin stem cell biology with special emphasis on updating current, state-of-the-art knowledge. Represented are discoverers and innovators responsible for the first isolation of stem cells, for the discovery of epidermal and follicular stem cells and of dermal mesenchymal stem cells, for developing biodegradable microenvironments that promote stem cell-driven regeneration and organoids capable of growing hair, for epithelial stem cell manipulation capable of restoring vision, and for the discovery of skin cancer (melanoma) stem cells.
This intensive, two-day experience represents a unique opportunity to acquire insight and expertise in the role of stem cells in regenerative medicine, inflammation, and cancer.
Designed as in-person event, it seeks to bring together the local scientific community to set the stage for future collaborations. The back-to-back structure is meant to foster further interactions across the wider HSCI community.
Thursday, September 15
9:00-9:10am
Welcome | HSCI Cancer Program Leaders
Carla Kim, PhD
Boston Children's Hospital
Mario Suva, MD, PhD
Massachusetts General Hospital
9:10-9:55am
Bradley Bernstein, MD, PhD
Dana-Farber Cancer Institute
Modeling epigenetic lesions that cause glioma
9:55-10:40am
Marcos Simoes-Costa, PhD
Boston Children's Hospital
Metabolic regulation of the neural crest epigenome
10:40-10:55am | Break
10:55-11:40am
Dan Landau, MD, PhD
Weill Cornell Medical College, New York Genome Center
Somatic evolution mapped with single-cell multi-omics
11:40am-12:25pm | Poster Session
12:25-1:25pm | LUNCH
1:25-2:10pm
Judith Agudo, PhD
Dana-Farber Cancer Institute
Quiescent cancer stem cells evade anti-tumor immunity
2:10-2:55pm
Jason Buenrostro, PhD
Harvard University, Department of Stem Cell and Regenerative Biology
Single-cell Epigenomics: Gene regulation at unprecedented resolution
2:55-3:10pm | Break
3:10-3:55pm
Nada Kalaany, PhD
Boston Children's Hospital
Metabolic Dependencies in Pancreatic Cancer
3:55-4:05pm
Thank you and Closing | Carla Kim and Mario Suva
4:00-5:00 | Social Hour
Friday, September 16
8:00-8:05am
Opening Remarks
8:05-9:00am
Opening Keynote Speaker
Robert Lavker, PhD
Northwestern University Feinberg School of Medicine
Epithelial Stem Cells: Adventures in Dermato-ophthalmology
9:00-9:45am
Karl Koehler, PhD
Boston Children's Hospital
Modeling Human Skin Development
9:45-10:30am
Ya-Chieh Hsu, PhD
Harvard University, Department of Stem Cell and Regenerative Biology
Skin Deep: Stem Cells at the Nexus of the Niche, Physiology, and the External Environment
10:30-10:45am | Break
10:45-11:30am
Dennis Orgill, MD, PhD
Brigham and Women's Hospital
Skin Regeneration, from Bench to Bedside in 40 Years
11:30am-12:15pm
George F. Murphy, MD
Brigham and Women's Hospital
Skin Stem Cells as Effectors and Targets: New Insights from Psoriasis and GVHD
12:15-1:15pm | LUNCH
1:15-2:00pm
Natasha Frank, MD
Brigham and Women's Hospital
Developmental Plasticity of ABCB5-positive Stem Cells
2:00-2:45pm
Tobias Schatton, PhD, PharmD
Brigham and Women's Hospital
Leveraging Glyco-immuno-oncology for Optimizing Immune Checkpoint Therapy via Cell Type-directed Targeting
2:45-3:00pm | Break
3:00-3:45pm
Bruce Ksander, PhD
Harvard Medical School, Department of Ophthalmology
In Vivo Epigenetic Reprogramming to Reverse Age and Rejuvenate Cellular Functions
3:45-4:30pm
Markus Frank, MD
Boston Children's Hospital
The Therapeutic Promise of Dermal Mesenchymal Stem Cells
4:30-5:30pm
Closing Keynote Speaker
Irving Weissman, MD
Stanford Medicine, Institute for Stem Cell Biology and Regenerative Medicine
Normal and Neoplastic Stem Cells
5:30-6:00pm
Round Table Discussion: The Next Frontiers