#  Cancer Program 

 



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### Researchers in the HSCI Cancer Program are working to establish the crucial differences between normal stem cells and their cancerous counterparts.

The goal of the program is to develop therapies that can eradicate cancer cells – and their entire lineage – without harming healthy tissues. This ambitious goal demands a profound understanding of how, precisely, a normal stem cell becomes a cancer cell. Some of the world’s foremost cancer researchers are collaborating across Harvard's schools and hospitals to do just that.

## Our goals:

- Identify the critical genes and pathways that distinguish cancer from normal stem cells.
- Pinpoint which of these – in what combination – could serve as candidate targets for therapy.

## What we have achieved so far:

HSCI Cancer Program scientists have:

- Isolated normal stem cell populations from intestine and colon tissue, and characterised their molecular profiles extensively.
- Identified and investigated key pathways operating in lung-tumor-propagating cells.
- Demonstrated what factors are required for leukemia stem cell development and survival.
- Clarified the role of a specific mutation that controls signaling in tumor-propagating cells in human pancreatic tumors.
- Developed imaging technologies for visualizing single tumor-initiating stem cells in the laboratory.



 

##  Program Leaders: 

 



  [### Carla F. Kim, Ph.D.

 ](/people/carla-f-kim-phd)Boston Children's Hospital

Harvard Medical School

 

 

 

      ![Carla Kim Harvard Medical School news 2018](/sites/g/files/omnuum10026/files/styles/hwp_4_5__690x865/public/hsci/files/kim_carla_hms_2018.jpg?itok=mDi6NDGu) 

 

 

 

   [### Mario Suva, M.D., Ph.D.

 ](/people/mario-suva-md-phd)Associate Professor of Pathology, Harvard Medical School and Massachusetts General Hospital

Neuro-Oncology Program, Dana-Farber/Harvard Cancer Center

Institute Member, Broad Institute of MIT and Harvard

 

 

 

      ![Portrait of Mario Suva, M.D., Ph.D.](/sites/g/files/omnuum10026/files/styles/hwp_4_5__690x865/public/hsci/files/suva_mario_cropped_1.jpg?itok=-gzA6fhs) 

 

 

 

  

 

 

 

 

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   [### HSCI faculty member appointed the inaugural Regenerative Biology Endowed Chair at Boston Children’s Hospital

 ](/news/fernando-camargo-regenerative-biology-endowed-chair) March 04, 2022 

 

  

 

 [ More research news arrow\_circle\_right ](/news)