Jeffrey Karp, PhD
- Brigham & Women's Hospital
- Harvard Medical School
- Harvard-MIT Division of Health Sciences and Technology
Jeff Karp is an Associate Professor at Harvard Medical School, Brigham and Women's Hospital. He is Principal Faculty at the Harvard Stem Cell Institute and is Affiliate Faculty at MIT through the HST program.
His research focuses on Stem Cell Engineering (towards elucidating basic mechanisms mediating the homing of Mesenchymal Stem Cells that drive innovative engineered solutions to control the fate and function of cells post-transplantation), Biomaterials (studying degradable prodrug-based self-assembled hydrogels as controlled drug-delivery systems), and Medical devices such as cell sorting chips that can be used to sort cells for diagnostic or therapeutic applications, needles that sense travel through tissues, or Gecko-inspired medical adhesives that was recently selected as one of Popular Mechanic's "Top 20 New Biotech Breakthroughs that Will Change Medicine”. He also invented several technologies that have been internationally recognized including a new neonatal adhesive that can be quickly removed without damage, nanosensors that can be used to visualize cell-cell communication in real-time, and a nanoparticle prophylactic approach to prevent contact dermatitis.
Dr. Karp has published more than 80 peer-reviewed papers and book chapters, 60 abstracts, has given over 100 national and international invited lectures and has 30 issued or pending patents, a number of which have been licensed by biotech companies. Dr. Karp's work has been recognized by CNN, NPR Science Fridays, Boston Globe, ABC News, MSNBC, CBC Quirks and Quarks, CanadaAM, BBC, Forbes, National Geographic, Popular Science, the Washington Post, the New York Post, and by Wired Magazine.
In 2011 the Boston Business Journal recognized Dr. Karp as a Champion in Healthcare Innovation. MIT’s Technology Review Magazine (TR35) also recognized Dr. Karp as being one of the top innovators in the world under the age of 35. He received the 2010 Coulter Foundation Translational Young Investigator Award and the 2011 Society for Biomaterials Young Investigator Award. He currently serves as the Biology and Medicine Section Editor for the Journal Nanotechnology. In 2012, two KarpLab postdocs received the MIT TR35 award (Weian Zhao and Bryan Laulicht). Dr. Karp was also elected in 2013 to the American Institute for Medical and Biological Engineering's College of Fellows.
Dr. Karp is also an acclaimed mentor. He was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT in 2008 and received the 2010 HST McMahon Mentoring award for being the top mentor among all faculty who mentor Harvard-MIT students. To date, 12 postdocs from his laboratory have secured faculty positions at institutions throughout the world (USA, Korea, Ireland, Singapore, and India). Jeff obtained a Ph.D. from the University of Toronto in 2004 at IBBME/Chem Eng where he worked with Professor John Davies and Molly Shoichet. Upon graduation, he was awarded the Paul B. Madsen Award for Innovation. He trained at MIT as an NSERC Postdoctoral Fellow working in Institute Professor Robert Langer's laboratory from 2004-2007.
mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation.
Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM.
Blood. 2013 Aug 26. [Epub ahead of print]
Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns.
Bose S, Singh R, Hanewich-Hollatz M, Shen C, Lee CH, Dorfman DM, Karp JM, Karnik R.
Scientific Reports. 2013 Jul 31;3:2329
A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue.
Yang SY, O'Cearbhaill ED, Sisk GC, Park KM, Cho WK, Villiger M, Bouma BE, Pomahac B, Karp JM.
Nature Communications. 2013 Apr 16;4:1702
Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials.
Vemula PK, Wiradharma N, Ankrum JA, Miranda OR, John G, Karp JM.
Current Opinion in Biotechnology. 2013 Mar 1.
A highly tunable biocompatible and multifunctional biodegradable elastomer.
Pereira MJ, Ouyang B, Sundback CA , Lang N, Friehs I, Mureli S, Pomerantseva I, McFadden J, Mochel MC, Mwizerwa O, del Nido P, Sarkar D, Masiakos PT, Langer R, Ferreira LS*, and Karp JM*.
Advanced Materials. 2013 Feb 25;25(8):1209-15
Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal.
Cho WK, Ankrum JA, Guo D, Chester SA, Yang SY, Kashyap A, Campbell GA, Wood RJ, Rijal RK, Karnik R, Langer R, Karp JM.
Proceedings of the National Academy of Sciences. (COVER FEATURE, 2012, Dec 10, Highlighted as “Editor’s Choice” in Science Translational Medicine)
Quick Release Medical Tape.
Laulicht B, Langer R, Karp JM.
Proceedings of the National Academy of Sciences. 2012 Nov 13;109(46):18803-8
A Bioinspired Multivalent DNA Network for Capture and Release of Cells.
Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GSL, Phillips JA, Dorfman DM, Karnik R, Karp JM.
Proceedings of the National Academy of Sciences. 2012 Nov 27;109(48):19626-31. Epub 2012 Nov 12.
A portable chemotaxis platform for short and long term analysis.
Xu C, Poh YK, Roes I, O'Cearbhaill ED, Matthiesen ME, Mu L, Yang SY, Miranda-Nieves D, Irimia D, Karp JM.
PLoS One. 2012;7(9):e44995
Mesenchymal Stem Cells Transmigrate Between and Directly Through TNF-a-activated Endothelial Cells.
Teo GST, Ankrum JA, mArtinelli R, Boetto SE, Simms K, Sciuto TE, Dvorak AM, Karp JM, Carman CV.
Stem Cells. 2012 Aug 7. PMC3479371
Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticle Loaded Poly(lactide-co-glycolide) Microparticles.
Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM.
Nano Lett. 2012 Aug 8;12(8):4131-9. Epub 2012 Jul 12. PMC3552518.
Engineered cell homing.
Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM.
Blood. 2011 Oct 27.
Cell-surface sensors for real-time probing of cellular environments.
Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM.
Nat Nanotechnol. 2011 Jul 17;6(8):524-31.
Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions.
Zhao W, Loh W, Droujinine IA, Teo W, Kumar N, Schafer S, Cui CH, Zhang L, Sarkar D, Karnik R, Karp JM.
FASEB J. 2011 Sep;25(9):3045-56. Epub 2011 Jun 7.
Nanoparticles reduce nickel allergy by capturing metal ions.
Vemula PK, Anderson RR, Karp JM.
Nat Nanotechnol. 2011 May;6(5):291-5. Epub 2011 Apr 3.
Design of a mechanical clutch-based needle-insertion device.
Bassett EK, Slocum AH, Masiakos PT, Pryor HI 2nd, Farokhzad OC, Karp JM.
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5540-5.
Mesenchymal stem cell homing: the devil is in the details.
Karp JM, Leng Teo GS.
Cell Stem Cell. 2009 Mar 6;4(3):206-16. Review.
A biodegradable and biocompatible gecko-inspired tissue adhesive.
Mahdavi A, Ferreira L, Sundback C, Nichol JW, Chan EP, Carter DJ, Bettinger CJ, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos PT, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM.
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2307-12.
Nanocarriers as an emerging platform for cancer therapy.
Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R.
Nat Nanotechnol. 2007 Dec;2(12):751-60. Review.