Research Newsletter - March 2009
Spotlight
In an article paper published in Nature, HSCI Principal Faculty Member Pier Paolo Pandolfi and colleagues report that ETS genetic rearrangements may represent progression events rather than initiation events in prostate tumorigenesis.
ETS rearrangements and prostate cancer initiation
Abstract:
The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation specific) transcription factor (ERG or ETV1) to the TMPRSS2 promoter region, which contains androgen responsive elements. The TMPRSS2:ERG genetic rearrangement has been reported to occur in approximately 40% of primary prostate tumours (ETV1 genetic rearrangements occur at a much lower frequency), and it results in the aberrant androgen-regulated expression of ERG. Tomlins et al. concluded that ETS genetic rearrangements are sufficient to initiate prostate neoplasia. However, here we show that ETS genetic rearrangements may in fact represent progression events rather than initiation events in prostate tumorigenesis. To this end, we demonstrate that the prostate-specific overexpression of ERG does not initiate prostate tumorigenesis.
Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. ETS rearrangements and prostate cancer initiation. Nature. 2009 Feb 12;457(7231):E1; discussion E2-3. Read paper.
Review and Commentary
Donahoe PK. A pediatric surgeon retools in genetics and genomics to study congenital diaphragmatic hernia. J Pediatr Surg. 2009 Feb;44(2):307-11.
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Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development. 2009 Feb;136(4):509-23.
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Williams DA. New approaches in the potential treatment of HIV-acquired immunodeficiency disease. Mol Ther. 2009 Feb;17(2):209-10.
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Cerletti M, Shadrach JL, Jurga S, Sherwood R, Wagers AJ. Regulation and Function of Skeletal Muscle Stem Cells. Cold Spring Harb Symp Quant Biol. 2009 Feb 9. [Epub ahead of print.]
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Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev. 2009 Feb;19(1):51-9. Epub 2009 Feb 11.
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Nakano A, Nakano H, Chien KR. Multipotent Islet-1 Cardiovascular Progenitors in Development and Disease. Cold Spring Harb Symp Quant Biol. 2009 Feb 9.
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Blood
Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood. 2009 Feb 2. [Epub ahead of print]
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Busque L, Paquette Y, Provost S, Roy DC, Levine RL, Mollica L, Gilliland DG. Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies. Blood. 2009 Feb 6. [Epub ahead of print]
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Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B cell homeostasis. Blood. 2009 Feb 11. [Epub ahead of print]
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Cancer
Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. ETS rearrangements and prostate cancer initiation. Nature. 2009 Feb 12;457(7231):E1; discussion E2-3.
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Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci USA. 2009 Feb 24;106(8):2712-6. Epub 2009 Feb 5.
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Cardiovascular System
Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR, Pu WT. microRNA-1 negatively regulates expression of the hypertrophy-associated genes calmodulin and Mef2a. Mol Cell Biol. 2009 Feb 2. [Epub ahead of print]
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Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA. The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2009 Feb 21. [Epub ahead of print]
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Developmental Biology
Wang Y, Zhou Z, Walsh CT, McMahon AP. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci USA. 2009 Feb 24;106(8):2623-8. Epub 2009 Feb 5.
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Imaging
Devaraj NK, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009 Feb;20(2):397-401.
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Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R. Normalized Born ratio for fluorescence optical projection tomography. Opt Lett. 2009 Feb 1;34(3):319-21.
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Muscular System
Mizuno Y, Guyon JR, Okamoto K, Kunkel LM. Expression of synemin in the mouse spinal cord. Muscle Nerve. 2009 Feb 19. [Epub ahead of print]
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Renal System
Kramer AB, van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal Kidney injury molecule-1 (Kim-1) over time. Am J Physiol Renal Physiol. 2009 Feb 18. [Epub ahead of print]
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Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol. 2009 Mar;20(3):672-9. Epub 2009 Feb 25.
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Technology
Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 6;4(2):103-6.
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Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb;48(2):155-70.
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McClean MN, Hersen P, Ramanathan S. In vivo measurement of signaling cascade dynamics. Cell Cycle. 2009 Feb 1;8(3):373-6. Epub 2009 Feb 17.
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Nilsson B, Johansson M, Al-Shahrour F, Carpenter AE, Ebert BL. Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution. Bioinformatics. 2009 Feb 19. [Epub ahead of print]
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Tissue Engineering
Abukawa H, Zhang W, Young CS, Asrican R, Vacanti JP, Kaban LB, Troulis MJ, Yelick PC. Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs. J Oral Maxillofac Surg. 2009 Feb;67(2):335-47.
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Geisse NA, Sheehy SP, Parker KK. Control of myocyte remodeling in vitro with engineered substrates. In Vitro Cell Dev Biol Anim. 2009 Feb 28.
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