HSCI Affiliated Faculty member Albert Edge, PhD, describes how his team induced cochlear hair cell regeneration and restored hearing to deaf mice.
Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron. 2013 Jan 9;77(1):58-69. doi: 10.1016/j.neuron.2012.10.032.
A scientific collaborative established to fulfill the promise of stem cell biology.
HSCI Science Update: February 2013
February 27, 2013
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Finding the Path to Restored Hearing
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From iPS to Hematopoietic by Way of Mouse
HSCI Blood Diseases Program leader, Daniel Tenen, MD, describes how his team was able to use an in vivo system to generation human hematopoietic cells from induced pluripotent stem cells.
Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2012 Dec 4.
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Mapping Out the Reprogramming Road
HSCI Principal Faculty member Konrad Hochedlinger, PhD, describes new insights into the nature and sequence of molecular events involved in creating induced pluripotent stem cells.
Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K. A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells. Cell. 2012 Dec 21;151(7):1617-32. doi: 10.1016/j.cell.2012.11.039.