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HSCI Science Update: December 2012

December 21, 2012

 

  • Getting Control of iPS Cell Lines

    HSCI iPS Core Facility Co-Director Chad Cowan, PhD, describes the application of newly developed tools to specifically edit the genome and also solve the fundamental problem of creating a control when using iPS cells to study a disease in a dish.

    Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models. Cell Stem Cell. 2012 Dec 12. doi:pii: S1934-5909(12)00645-5.

  • Jump-Starting New Gene Formation

    HSCI Principal Faculty member John Rinn, PhD, describes a particular type of "jumping gene's" unusual expression and proximity to RNA genes that are associated with progenitor cells.

    Kelley DR, Rinn JL. Transposable elements reveal a stem cell specific class of long noncoding RNAs. Genome Biol. 2012 Nov 26;13(11):R107.

  • Going Nano to Go After Cancer

    HSCI Principal Faculty member Khalid Shah, PhD, describes the pharmacokinetics and efficacy of a stem cell-based targeted therapy in highly malignant glioblastoma with clinical implications.

    van de Water JA, Bagci-Onder T, Agarwal AS, Wakimoto H, Roovers RC, Zhu Y, Kasmieh R, Bhere D, Van Bergen en Henegouwen PM, Shah K. Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16642-7.