Gene silencing may cause limitations of induced pluripotent stem cells
"These findings indicate we need to keep improving the way we produce iPSCs and suggest the need for new reprogramming strategies," Konrad Hochedlinger said.
Harvard News Office file photo
Scientists may be one step closer to being able to generate any type of cells and tissues from a patient's own cells, according to the results of a new study by Harvard stem cell researchers at Massachusetts General Hospital.
HSCI Principal Faculty member Konrad Hochedlinger, PhD, and colleagues describe finding that an important cluster of genes is inactivated in induced pluripotent stem cells (iPS) that do not have the full development potential of embryonic stem cells. Generated from adult cells, iPS have many characteristics of embryonic stem cells but also have had significant limitations.
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