The goal of our research program is to characterize bone marrow niche-induced signaling pathways controlling normal and neoplastic hematopoietic stem and progenitor cell growth and survival. A major effort of the lab has been directed to establish the use Laser Scanning Cytometry (LSC) in murine bone marrow sections. LSC is a novel technology, which provides high resolution imaging and cytometric measurements of whole tissue sections at a single cell level, thereby allowing quantitative measurements of defined hematopoietic cell subsets including rare cells, within the bone marrow microenvironment. Quantitative imaging of BM will be used in different murine leukemia models to analyze the frequency, localization and distribution of previously described rare leukemia initiating cells, as well as the effect of pharmacologic and gene therapy anti-leukemic treatments in the dissemination and progression of leukemia in different organs. A multidisciplinary approach combining biochemistry, cell biology, genetics and confocal imaging will be required. Previous experience with murine models of leukemia will be highly considered.

For more information, please see the following website: http://www.childrenshospital.org/cfapps/research/data_admin/Site188/main...

To apply, email a cover letter, curriculum vitae, statement of research experience and career goals, and contact information for three references addressed to Dr. Leslie Silberstein, Director Joint Program in Transfusion Medicine. Emails should be sent to Lauren Smith, Administrative Assistant, at Lauren.Smith@childrens.harvard.edu.

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