Postdoctoral Position
Post Doctoral Position in differentiation and self-renewal of Hematopoietic Stem Cells and Memory T cells.
A post doctoral position is available in the laboratory of Dr. John Luckey, M.D., Ph.D., (Brigham and Women's/Harvard Medical School) to dissect key molecular mechanisms that regulate the generation and maintenance of hematopoietic stem cells and memory T cell populations. The laboratory's research focus is to understand the molecular events that are responsible for generation and maintenance of self-renewing hematopoietic populations in vivo. As the only adult hematopoietic populations that undergo long-term self-renewal, we have previously shown that memory cells and long-term hematopoietic stem cells share molecular transcriptional pathways (see PNAS. 2006 Feb 28;103(9):3304-9). The major focus of this postdoctoral position will be to determine which of these shared transcripts play a functional role in memory T cells and hematopoietic stem cells. The research goals designed for this position have direct relevance to bone marrow transplantation therapy for human malignancy as well as vaccine development for preventing infectious diseases.
Minimum requirements for this position include a Ph.D. and/or M.D., and experience in molecular or cell biology. This is a unique post-doctoral opportunity for someone trained as a cellular immunologist who wishes to broaden their focus to include stem cell biology. This position is intended for mature and exceptional candidates who have a strong desire to work in a multidisciplinary environment and expand their expertise in molecular and cellular biology as well as mouse models of developmental biology. The successful candidate will participate directly and significantly in the generation of new mouse models to study both memory T cells and hematopoietic stem cells. Specific research activities will include working with mouse model systems to generate viral specific T cells through in vivo infection, multi-color flow-cytometric cell sorting of rare T cell populations ex vivo, targeted enrichment of protein and post-translational modification classes, and quantitative mass spectrometry.
Interested candidates should submit electronic copy of their curriculum vitae, along with complete contact information for at least three references, and a cover letter describing their past research experience, career goals and a statement of future research interests to:
Dr. John Luckey, M.D., Ph.D.
Email: cluckey@partners.org
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